Cancer development/progressionProgression:Survival: plasma Ghrelin ↔ (2) GHS-R agonist ↔ (2) Lean body mass: GHS-R agonist  (2), ↔ Body weight: GHS-R agonist  (2) Appetite: GHS-R agonist Handgrip strength: GHS-R agonist ↔ (3) Fatigue: GHS-R agonist ↔. The gene discussed is GHSR; the disease is cancer.