Node Interleukin-6 (IL6) has second-highest betweenness centrality of 0.611 in the NSCLC network, which connects 6 proteins across three sub-networks: Cluster 1 (UBE2C); Cluster 2 (CXCL2); and Cluster 5 (SPP1, CP, GOLM1, CHRDL1) (Figure 2; Table S4). The gene discussed is SPP1; the disease is non-small cell lung carcinoma.