Another study found 16 hub genes (TEK, ANGPT1, MMP9, VWF, CDH5, EDN1, ESAM, CCNE1, CDC45, PRC1, CCNB2, AURKA, MELK, CDC20, TOP2A, and PTTG1) in NSCLC (95). This evidence concerns the gene MMP9 and non-small cell lung carcinoma.