RRM2 and non-small cell lung carcinoma: The top five genes targeted by highest number of down-regulated miRNAs in NSCLC are: (a) RRM2 targeted by 17 miRNAs; (b) BIRC5 targeted by 14 miRNAs; (c) CEP55 targeted by 12 miRNAs; (d) KIF2C targeted by 11 miRNAs; (e) CDK1 targeted by 9 miRNAs (Table S6).