It was experimentally showed that the TF FOXM1 binds to the promoter region of UBE2C and activates its high expression in esophageal squamous cell carcinoma, which supports our finding that the FOXM1 as an upstream regulator of UBE2C of Cluster 1 (Figure 3A) (53). This evidence concerns the gene TF and esophageal squamous cell carcinoma.