Another study found 16 hub genes (TEK, ANGPT1, MMP9, VWF, CDH5, EDN1, ESAM, CCNE1, CDC45, PRC1, CCNB2, AURKA, MELK, CDC20, TOP2A, and PTTG1) in NSCLC (95). Here, ESAM is linked to non-small cell lung carcinoma.