A phase II randomized study has started to evaluate the efficacy of anti-PD1 therapy (Pembrolizumab) with concurrent alphavirus-like replication particles containing self-amplifying replicon RNA for HER2 (VRP-HER2) vaccine in increasing the tumor infiltrating and peripheral blood immune response upon administration of the VRP-HER2 vaccine. This evidence concerns the gene ERBB2 and neoplasm.