This is advantageous compared to models of conditional Apc deletion, such as in Cdx2p-Cre; Apc+/Loxp mice (18, 19) or Fabpl-Cre; Apc15lox/+ mice (55) or Villin-Cre; Tp53Loxp/Loxp mice treated with AOM which require backcrossing to the FVB background (56). The gene discussed is FABP1; the disease is infectious otitis media.