To generate more colon tumors in a shorter experimental time, adult C57BL/6 mice carrying one CCL17-eGFP knock-in allele as a reporter for CCL17 expression received weekly AOM injections for 6 weeks, and were followed by clinical assessment until anemia was clinically apparent or other criteria for euthanasia were reached (Figure 1A). Here, CCL17 is linked to anemia.