CXCR2 and colonic neoplasm: In addition to CCL2, CXCR2 ligands including CXCL1, CXCL2, CXCL3, and CXCL8 produced by CRC cells and neutrophils themselves were found to be responsible for recruitment of CXCR2+ neutrophils/PMN-MDSCs to colon tumors (46–48).