These four subtypes are designed as (1) TiT (CD45−/CD68−), for homotypic CICs (hoCICs) formed between tumor cells; (2) LiT (CD45+/CD68−), for leukocytes inside tumor cells; (3) TiM (CD45−/CD68+), for tumor cells inside macrophages; and (4) LiM (CD45+/CD68+), for leukocytes inside macrophages. This evidence concerns the gene CD68 and neoplasm.