TGFB3 and cancer: SP100 was more internally positioned in 80% (4/5) of Gleason grade 4 and 5 cancer in which SP100 repositioned and TGFB3 was more internally positioned in 66.7% (2/3) of the Gleason grade 4 and 5 cancers in which TGFB3 was repositioned, compared to the PND (Table 4).