SATB1 and Familial prostate cancer: SATB1, a nuclear architectural protein that facilitates DNA loop formation and chromatin remodeling (Kohwi-Shigematsu et al., 2013), promotes the progression of many cancers, including prostate cancer, and is overexpressed in high Gleason score cancers compared to low Gleason score cancers and in metastatic compared to non-metastatic prostate cancers (Mao et al., 2013; Shukla et al., 2013; Naik and Galande, 2019).