Of the seven cancers with only one of the two genes more internally repositioned, SP100 was more internally repositioned in four and TGFB3 more internally positioned in three cancers (Table 1, Supplementary Table 7).Using a more internal position of at least one of SP100 or TGFB3 the false negative rate for detecting intermediate or high Gleason score cancers was reduced to 36.4% (4/11). The gene discussed is SP100; the disease is cancer.