HES5 and Familial prostate cancer: For instance, the positioning patterns of HES5 and FLI1 are highly indicative of cancer, with both HES5 and FLI1 repositioned in 100% of breast cancers and FLI1 repositioned in 92.9% of prostate cancers, compared to benign tissue controls (Meaburn et al., 2009; Leshner et al., 2016; Meaburn et al., 2016).