We also detected an established pathogenic variant for multiple endocrine neoplasia type 1 (MEN-1) syndrome, in MEN1 (ENST00000337652:c.778G > A, p.Glu260Lys, rs104894268) (Teh et al., 1998) in a non-index patient, diagnosed with BC and primary parathyroid hyperplasia at 50 years. Here, MEN1 is linked to Primary parathyroids hyperplasia.