SETBP1 and breast cancer: Although SETBP1:c.4129G > C missense variant is predicted to have a damaging effect by only one of seven prediction tools (LRT score = 0.0001619), it was shortlisted through two strategies (CGV and SVGU), was present in two GRBC-affected sisters (diagnosed with BC at 41 and 44 years of age) and in a single FBRCAX patient.