EZH2 and Miyoshi myopathy: Currently, tazemetostat (EPZ‐6438), another SAM competitive inhibitor with a high affinity for the wt and the mutant EZH2 forms, is being evaluated in clinical studies to treat R/R B-NHL and MM patients (NCT03456726) (Knutson et al., 2014; Gulati et al., 2018), reaching an overall response rate of 38% in a phase I clinical trial (Italiano et al., 2018).