Although no mutations have been reported in the genes coding for histone deacetylases (HDACs), several members of this family like HDAC1, 2, and 6 can be overexpressed in DLBCL, in association with a decrease in the DNA accessibility to the transcription machinery (Marquard et al., 2009). The gene discussed is HDAC1; the disease is diffuse large B-cell lymphoma.