Later on, EPZ0005687 and GSK126, two selective and SAM-competitive EZH2 inhibitors with a higher inhibitory capacity for the mutant EZH2 form, were developed and tested in DLBCL and FL (McCabe et al., 2012b; Knutson et al., 2014). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.