Moreover, combinations with EZH2 inhibitors and inhibitors of the BCR signaling cascade such as ibrutinib, the spleen tyrosine kinase (SYK) inhibitor tamatinib, the mammalian target of rapamycin (mTOR) inhibitor everolimus, or MAPK inhibitor have also been challenged in pre-clinical models of DLBCL (Brach et al., 2017; Lue et al., 2017). Here, BCR is linked to diffuse large B-cell lymphoma.