Consequently, CBP ablation has a direct impact on the quiescence, apoptosis, and self-renewal of adult hematopoietic stem cells (Chan et al., 2011) and CBP/p300 have a tumor suppressor role in mice models (Kung et al., 2000; Kang-Decker et al., 2004; Chan et al., 2011). This evidence concerns the gene EP300 and neoplasm.