Among other promising combinations, CPI203 combined with the proteasome inhibitor bortezomib or with lenalidomide was particularly efficient in aggressive bortezomib-resistant MCL tumors (Moros et al., 2014), and GS-5829 synergistically interacted with venetoclax or with BCR-interfering agents in preclinical models of DLBCL, MCL, and/or CLL (Bates et al., 2016; Kim et al., 2017). This evidence concerns the gene BCR and mantle cell lymphoma.