At the preclinical level, the pharmacological IDH2 inhibitor AGI-6780 displayed synergistic cytotoxicity in MCL and BL cell lines in combination with the proteasome inhibitor carfilzomib, mediated by the blockade of tricarboxylic acid cycle and the decrease in ATP levels, as a consequence of enhanced IDH2 enzymatic inhibition (Bergaggio et al., 2019). This evidence concerns the gene IDH2 and mantle cell lymphoma.