This agent displayed remarkable efficacy in different preclinical models of B-NHL, either as single agent or in combination with the BCL-2 antagonist venetoclax in DHLs (Esteve-Arenys et al., 2018), in DLBCL-ABC (Ceribelli et al., 2014) and in both ABC and GCB subtypes of DLBCL in combination with blockade of the CXCR4 chemokine receptor (Recasens-zorzo et al., 2018). Here, BCL2 is linked to aneurysmal bone cyst.