Combinations with chemical compounds that broadly affect an epigenetic mark and a specific inhibitor of a chromatin-modifying enzyme, such as the EZH2 inhibitor GSK126 and romidepsin, have also been assessed in preclinical studies with DLBCL-GCB cell lines, leading to synergistic tumor growth inhibition effects in mice (Lue et al., 2019). Here, EZH2 is linked to diffuse large B-cell lymphoma.