EZH2 and diffuse large B-cell lymphoma: Regarding EZH2 inhibitors, combinatorial treatments with tazemetostat and the anti-programmed death-ligand 1 (PDL1) antibody atezolizumab (NCT02220842), prednisone alone, or combined with other components of CHOP regimen are currently being evaluated in patients with refractory DLBCL (NCT02889523) (Gulati et al., 2018).