CREBBP and diffuse large B-cell lymphoma: For instance, deleterious and/or loss of function mutations in the histone acetyltransferase CREB binding protein (CREBBP) or the E1A binding protein 300 (EP330) have been reported in about 40% of DLBCL and FL patients as well as in other lymphoma subtypes (Morin et al., 2011; Pasqualucci et al., 2011b).