Indeed, recent works have reported an increase in PRMT1-related histone arginine methylation in DLBCL-GCB cells resistant to EZH2 inhibition, in association with BCL-2 overexpression and modulation of the B-cell receptor (BCR) downstream signaling, supporting the rational association of EZH2 and PRMT1 inhibitors in DLBCL patient samples (Goverdhan et al., 2017). Here, BCL2 is linked to diffuse large B-cell lymphoma.