EZH2 and acute myeloid leukemia: Other subsequent compounds directed specifically against EZH2 are the dual EZH2/1 inhibitors UNC1999, with a potent capacity to suppress H3K27me3 and H3K27me2 levels and to inhibit proliferation of mixed lineage leukemia (MLL)-rearranged cells, and the OR-S1 and OR-S2 inhibitors, which were assessed for the treatment of DLBCL, AML, and MM (Konze et al., 2013; Honma et al., 2017).