BCR and B-cell chronic lymphocytic leukemia: Nevertheless, we found that BCR stimulation is able to antagonize the repression of downstream signaling nodes and, noteworthy, significantly counteract the apoptotic cell death triggered by EC-7072, which was accompanied by upregulation of BCL2 gene expression, further supporting that the antileukemic activity of the compound may involve modulation of the basal BCR signaling status and the proapoptotic/antiapoptotic balance in CLL cells.