In agreement, Western blotting analysis showed an increase in the levels of the proapoptotic protein Noxa, while the antiapoptotic protein BCL-xL was decreased, in primary leukemia cells exposed to EC-7072 in a time-dependent manner, further supporting the proapoptotic properties of the mithralog in CLL (Supplementary Figure 6E). Here, PMAIP1 is linked to B-cell chronic lymphocytic leukemia.