Accordingly, signaling pathways that are engaged downstream of the BCR cascade (including NF-κB, JAK/STAT, and MAPK) were found altered in KEGG analysis of the differentially expressed genes, suggesting a profound dysregulation of the BCR signaling pathway in CLL cells brought about by EC-7072. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.