BCL2 and B-cell chronic lymphocytic leukemia: Along similar lines, the distinctive high levels of the antiapoptotic protein B-cell lymphoma 2 (BCL2) in CLL cells have opened a therapeutic window for molecules such as the recently FDA (Food and Drug Administration)-approved BCL2 antagonist venetoclax, which shows durable clinical activity in patients with relapsed or refractory disease when used alone or in combination with rituximab (17, 18).