Accordingly, KEGG pathway analysis of the protein-coding genes differentially expressed in CLL cells after EC-7072 treatment revealed an enrichment of multiple cascades engaged by the BCR-dependent signaling, such as NF-kB, JAK/STAT, PI3K/AKT, and MAPK pathways, with key roles in regulating gene transcription in CLL cells (38, 39) (Figure 4C, Supplementary Figure 6B and Supplementary Table 4). This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.