AKT1 and B-cell chronic lymphocytic leukemia: In this sense, and given that no changes in the phosphorylation levels of AKT1 at S473 were observed, the effect of the compound on additional residues known to be phosphorylated in response to AKT1 activation (e.g., T308) might bring to light a novel aspect of the antileukemic activity of EC-7072 in CLL.