Accordingly, KEGG pathway analysis of the protein-coding genes differentially expressed in CLL cells after EC-7072 treatment revealed an enrichment of multiple cascades engaged by the BCR-dependent signaling, such as NF-kB, JAK/STAT, PI3K/AKT, and MAPK pathways, with key roles in regulating gene transcription in CLL cells (38, 39) (Figure 4C, Supplementary Figure 6B and Supplementary Table 4). Here, BCR is linked to B-cell chronic lymphocytic leukemia.