SYK and B-cell chronic lymphocytic leukemia: Nevertheless, as shown in Figures 5A,B, these experiments revealed a significant reduction of the levels of phosphorylated (p)-SYK, p-BTK and p-PLCγ2 in isolated leukemia cells after 8 h of incubation with EC-7072, a treatment that does not result in noticeable CLL cell death (Supplementary Figure 9A).