Concomitantly, EC-7072 was able to downregulate the total amount of LYN, PLCγ2 and STAT3 in CLL cells, further reinforcing the broad transcriptional reprogramming of primary leukemia cells from patients with CLL upon exposure to the compound (Figure 5E and Supplementary Figure 10A). The gene discussed is PLCG2; the disease is B-cell chronic lymphocytic leukemia.