Murine: post-IRI 10-fold increase, DC depletion improves cardiac function post-MI (68), OR worsens LV function (69), increased DC worsen MI outcomes (70, 71), cDC2 increase numbers and CD40 expression in response to MI, prime autoreactive T cells, 4-fold increase, no functional role post-MI. The gene discussed is CD40; the disease is myocardial infarction.