In the same distal middle cerebral artery occlusion (dMCAO) stroke model of db/db mice, our previous study showed that compared to the non-hyperglycemic genetic control mice, T2D db/db mice had sustained hyperglycemia after stroke, elevated blood HbA1c level, hyperinsulinemia, and lowered serum adiponectin level (20). The gene discussed is ADIPOQ; the disease is stroke disorder.