KIR3DL1 and cancer: However, based on data claiming that the anti-KIR antibody can rapidly detune NK cell function in vitro and in cancer patients (209), thereby limiting its therapeutic efficacy, and given the pre-clinical data indicating that KIR blockade augments ADCC (206, 208), better responses are likely to be achieved when combining KIR blockade with other drugs that boost NK cell cytotoxicity.