The recent success of anti-NKG2A mAb on clinical trials unleashes its role as a promising checkpoint inhibitor in treating cancers with minimum side effects, and the success of NKG2A blockade also points out the importance of NK cells in anti-tumor immunity and advances the idea that combined reversal of both T and NK cell exhaustion is truly important in anti-tumor immunotherapy. Here, KLRC1 is linked to neoplasm.