It is also important to note that TIGIT inhibits IFN-γ secretion of both CD8+ T cells and NK cells in the above mentioned colorectal tumor models; interestingly, CT26 tumor-bearing TIGIT knockout (KO) mice develop tumors early after NK cells are depleted, suggesting that NK cells and T cells collaborate to eliminate tumors (68). Here, TIGIT is linked to colorectal neoplasm.