Indeed, TIGIT−/− mice show no resistance to lung metastasis in three different experimental lung metastasis models (B16F10, murine melanoma cell line; RM-1, murine prostate cancer cell line; E0771, murine breast cancer cell line) (63); moreover, TIGIT expression on NK cells is not significantly different between pancreatic cancer patients and healthy controls (64). This evidence concerns the gene TIGIT and breast cancer.