If these phenomena occur in humans in vivo, then phytocannabinoids could enhance chronic periodontitis, at least in part, by promoting microbial dysbiosis through direct toxic effects on specific oral bacteria or by aiding initial colonization through compromised IgM production; by compromising innate cell vitality; and/or through a suppressed innate response to periodontal pathogens. This evidence concerns the gene CD40LG and periodontitis.