The M2 profile of macrophages reported for some sarcoid granulomas may also be associated with the expression and activity of PPAR-γ, as PPAR-γ deficiency was observed in alveolar macrophages of pulmonary sarcoidosis patients (206) and its expression was shown to negatively correlate with disease severity (207). The gene discussed is PPARG; the disease is pulmonary sarcoidosis.