The fact that multiple injections of DTEGF13 were tolerated in the animals is important because human EGF and IL-13 are cross-reactive with mouse EGFR and IL-13R, thereby showing a higher specificity of DTEGF13 for tumor cells and lower safety concerns (Stish et al., 2008; Oh et al., 2009). Here, EGFR is linked to neoplasm.