NLRP3 can recognize a variety of ligands and provide a platform for caspase-1 activation, leading to the maturation and secretion of cytokine precursors pro-IL-1β and pro-IL-18 and ultimately leading to the development of inflammatory responses, which are important for many diseases such as infectious, inflammatory, and immune diseases (27–30). The gene discussed is IL1B; the disease is immune system disorder.