NLRP3 and Alzheimer disease: Researchers have reported that NLRP3 inflammasome is associated with a range of aseptic inflammatory diseases such as diabetes (11), arteriosclerosis (12), systemic lupus erythematosus (13), rheumatoid arthritis (14), and central nervous diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) (15, 16).