In particular, Davern and colleagues showed that the number of neurons expressing c-Fos, a protein marker of recent neuronal activation (Li and Dampney, 1992), in the DMH, the paraventricular hypothalamus (PVN), the central amygdala, and the MeAm of BPH/2 mice was markedly greater compared with BPN/3 mice (Davern et al., 2009). This evidence concerns the gene FOS and benign prostatic hyperplasia.