A major characteristic of the BPH/2 strain is a markedly exaggerated day-night difference in BP, HR, and activity compared to the normotensive BPN/3 (Jackson et al., 2014b), C57/Bl6 (Davern et al., 2009), and hypertensive BPH/ApoE mice (Figure 1; Al-Sharea et al., 2019). This evidence concerns the gene APOE and benign prostatic hyperplasia.