In 2001, Leckie described a larger depressor effect of the ACE inhibitor captopril in BPH/2 mice (Leckie, 2001), but plasma renin levels and renin enzyme activity were reportedly similar among BPN/3, BPH/2, and BPL/1 mice (Iwao et al., 1984). This evidence concerns the gene REN and benign prostatic hyperplasia.