However, there are conflicting findings with regard to renin activity in the submandibular glands of BPH/2 mice, regarding whether it is comparable with BPN/3 mice or greater in BPH/2 mice (Iwao et al., 1984; Uddin et al., 2003a; Uddin and Harris-Nelson, 2004). The gene discussed is REN; the disease is benign prostatic hyperplasia.