Using a large dose of losartan for 14 days [150 mg/kg/day, angiotensin II type 1 receptor (AT1R) antagonist], Palma-Rigo and colleagues found little difference between the hypertension induced by the drug in both strains, which was in the order of 23–25 mmHg (Palma-Rigo et al., 2011). The gene discussed is AGTR1; the disease is hypertensive disorder.