In a mouse high-fat diet-induced atherosclerosis model, TRPA1 was localized mainly in macrophages; TRPA1 channel activation with AITC suppressed the progression of atherosclerosis in apolipoprotein E (apoE)−/− mice, while the protective effect was lost in apoE−/−TRPA1−/− mice. This evidence concerns the gene TRPA1 and atherosclerosis.