TKT and chronic myelogenous leukemia, BCR-ABL1 positive: At the molecular level, this translocation generates the BCR-ABL oncogene (Andreieva et al., 2016), which encodes a constitutively activated tyrosine kinase (TK), which is the cause of Ph-positive (Ph+) CML and Ph+ acute lymphoblastic leukemia (ALL) (Quintás-Cardama et al., 2009).