Based on the integrated result of the protein–protein network (14 interactive proteins from the predicted gene set A) and pathway enrichment analysis (3 interactive proteins from the predicted gene set B), we finally identified 15 genes (ADAMTS2, ADAMTS3, ADAMTS14, COL4A6, COL5A2, COL8A1, COL19A1, COL20A1, COL21A1, COL22A1, COL24A1, COL27A1, COL28A1, TLL1, WNT8B) as the potential causal genes to OI disease. This evidence concerns the gene COL4A6 and osteogenesis imperfecta.