COL5A2 and osteogenesis imperfecta: Evidences in MGI shows that mice with COL5A2 mutation present abnormal cardiovascular system physiology, abnormal skeleton development, abnormal cutaneous collagen fibril morphology, abnormal cornea morphology, embryonic lethality during organogenesis, neonatal lethality, respiratory distress, thin dermal layer, and other phenotypes (Chen et al., 2017), most of these phenotypes are very similar to the human phenotypes of OI, therefore, we suggest that the COL5A2 gene is tightly correlated with OI, especially OI type II.