Among the three identified potential new risk factors to OI, ADAMTS2 and COL5A2 seem to be more associated with OI than COL8A1. In fact, ADAMTS2 is highly expressed in the skin, bones, tendons, and aorta and has a strong correlation with type I collagen (Bekhouche and Colige, 2015). The gene discussed is COL5A2; the disease is osteogenesis imperfecta.