TRPV2 and cancer: We hypothesized that activation of TRPV2 by virtue of opening aqueous pores, which are permeable for the protonated fraction of doxorubicin, will facilitate the permeation of doxorubicin and therefore augment its cytotoxic effect on TRPV2-expressing cancer cells, while sparing other cell types and therefore minimizing off-target side effects, as the effective concentration of doxorubicin can be lowered.