Here, we sought to examine whether a pore of TRPV2 channels expressed by a murine model of hepatocellular carcinoma cells [BNL1 ME (Kuriyama et al., 1999; Tatsumi et al., 1999; Ogunwobi and Liu, 2011)] could be used to shuttle doxorubicin into these cells selectively. The gene discussed is TRPV2; the disease is hepatocellular carcinoma.