We therefore hypothesize that CBD may amplify the efficacy of the doxorubicin-mediated effect specifically in cancer cells by (1) providing selective entry of doxorubicin into cancer cells via TRPV2 activation (see Figure 3) and by (2) enhancing doxorubicin accumulation by P-gp ATPase inhibition. The gene discussed is TRPV2; the disease is cancer.