Klotho is upregulated by resveratrol (Hsu et al., 2014a), testosterone (Hsu et al., 2014b), statins (Kuwahara et al., 2008), Rhein (Zhang et al., 2017), and hydrogen-rich saline (Chen et al., 2017) in both the cells and tissues of animals with kidney disease. Here, KL is linked to kidney disorder.