Patients (n = 90) with unresectable stages III to IV melanoma were treated with extended dose of nivolumab (1, 3, or 10 mg/kg) with or without peptide vaccines (MART-1/NY-ESO-1/gp100 with Montanide ISA 51 VG) (Kudchadkar et al., 2012). Here, PMEL is linked to melanoma.