Likewise, at the 2018 American Association for Cancer Research Annual Meeting, preliminary data from phase Ib trial of pembrolizumab plus intratumoral TLR9 agonist CMP-001, a CpG-A oligodeoxynucleotide packaged in virus-like particles, demonstrated a remarkable improvement in ORR of 33% for advanced melanoma previously resistant to anti–PD-1 therapy (Milhem et al., 2018). The gene discussed is TLR9; the disease is melanoma.