In conclusion, this study suggests the roles of H. erinaceus mycelium components, erinacine A–induced apoptosis, and the histone modification (H3K9K14ac) of the TNFR, Fas, and FasL promoters by the JNK/p300/NFκB p50 signaling pathways in human DLD-1 cancer cells. This evidence concerns the gene EP300 and cancer.