Inhibition of HDAC activity may occur in human colon cancer cells, with an increase in histone H3 acetylation in extensive histone modification statuses, such as induction of TNFR, Fas, FasL, and p21 genes, via histone acetyltransferase (HAT) p300 (Bolden et al., 2006; Kouzarides, 2007; Rajendran et al., 2011). This evidence concerns the gene EP300 and colonic neoplasm.