Previous studies have shown that a number of dried fruit body Hericium erinaceus extractions could reduce the expression of MMP-2 and MMP-9 in human colon cancer and invasion through modulations of the phosphorylation of ERK, JNK, and p38 MAPK (Kim et al., 2011; Kim et al., 2013; Lee et al., 2014). This evidence concerns the gene MAPK8 and colonic neoplasm.