CD8A and melanoma: (αGC+OVA)-EVs induced strong innate and OVA-specific adaptive immune response.(αGC+OVA)-EVs were induced γδ T cell-dependent, iNKT cell-mediated and OVA-specific T and B cell mediated immunity.In vivoB16-OVA melanoma modelTherapeutic vaccination (IV) of mice with (αGC+OVA)-EVs resulted in:↓ tumour growth↑ tumour infiltration with antigen-specific CD8+ T cells,↓ median survivalIn comparison with melanoma-bearing mice immunized with soluble αGC and OVA.Boosting vaccination with (αGC+OVA)-EVs further ↑ effects of treatment.