TGFB1 and neoplasm: Together with these effects, AFP-EVs reshaped the tumor microenvironment by attracting CD8+ T-lymphocytes to tumor sites and causing an increase in the levels of the immunostimulatory cytokines IFN-γ and IL-2 combined with reductions in immunosuppressive CD25+FoxP3+ T-regulatory cells and the levels of the immunosuppressive cytokines IL-10 and TGF-β (Lu et al., 2017).