However, EVs derived from necrotic B16 cell-loaded DCs treated with poly(I:C) were the most efficient and induced robust activation of melanoma-specific CD8+ T cells in tumor-draining lymph nodes, spleen, and tumor tissues and recruited NK and NK-T cells to the tumor site, resulting in drastic inhibition of tumor growth and an increase in survival in tumor-bearing animals (Damo et al., 2015). Here, CD8A is linked to melanoma.