CD80 and neoplasm: It is known that DC-derived EVs carry functionally active molecules on their surfaces that take part in immunological synapses—complexes of MHC class I and II with tumor antigens, as well as co-stimulatory and adhesion molecules (such as CD80, CD86, and CD40)—needed for the induction of anti-tumor T-cell immune responses (Munich et al., 2012).