CD8A and neoplasm: Using a mouse B16-OVA melanoma model it was demonstrated that DC-derived EVs loaded with OVA/αGC caused significant retardation of tumor growth, promoted infiltration of tumor tissues with antigen-specific CD8+ T cells, and increased the median survival time of tumor-bearing mice in comparison with those treated with a combination of soluble OVA and αGC (Gehrmann et al., 2013).