S1PR1 and neoplasm: intrathecal catheters or osmotic minipump for administration of compounds like fingolimod, D24 or D25, bortezomib injection intra peritoneal, S1pr1 silencing with 27mer dicer-substrate silencer RNA (DsiRNA), mechanical allodynia and hyperalgesia tests via von Frey and the Randall and Sellitto paw pressure test, mass spectrometry, Western Blot analysis, S1PR1 knockdown PCR, immunofluorescence, cytokine assay via multiplex cytokine kit, in vitro whole-cell recordings, tumor cell-killing assay via MTT assay