Our previous study had shown that Aconiti Lateralis Radix Praeparata (ALRP, Fuzi in Chinese) had an effect on anti-acute HF by enhancing mitochondrial biogenesis via Sirt1/PGC-1a pathway (Lu et al., 2017) and anti-CHF by promoting energy metabolism via PPARα/PGC-1α/Sirt3 pathway (Wen et al., 2019). Here, PPARGC1A is linked to hydrops fetalis.