Dkk-1 appears to play a role in chronic inflammation (Diarra et al., 2007; Sato et al., 2010; Chae et al., 2016), which has been implicated in the neuropathological profile of AD (Uchihara et al., 1997; Vehmas et al., 2003). Here, DKK1 is linked to Alzheimer disease.