APOE and Alzheimer disease: As we can see that from Table 4, single modality biomarkers (sMRI and APOE genotype) achieved a good performance for AD vs. HC and MCIs vs. MCIc (using all 246 extracted features and as well as with two APOE genotype feature from each subject) groups, when compared with the obtained outputs reported before (Zhang et al., 2011; Young et al., 2013).