As the A/T/N system defines that each modality of biomarkers offers a different complementary information, which is useful for the early classification of AD and MCI subjects, so in our study we have used four different modalities of biomarkers, sMRI, FDG-PET, CSF (biochemical protein level), and APOE genotype for the early prediction of AD and MCI subjects. This evidence concerns the gene APOE and Alzheimer disease.