In this study, there were four classes of data, AD, MCIc, MCIs, and HC, separated using four different types of biomarker, sMRI and FDG-PET for imaging modalities, and CSF as a biochemical (or fluid vessel) that show results reflecting the formation of amyloid plaques inside the brain, and APOE genotypes as genetic features. This evidence concerns the gene APOE and Alzheimer disease.