Accordingly, using the validated murine FXS model employing Fmr1−/y mouse strain (Bakker et al., 1994), we have shown that FMRP deficiency in the retina generates significant abnormalities in proteins contents and cellular alterations leading to defected signal transmission between photoreceptor cells and the inner retina, measured by the electroretinogram (ERG) technique (Rossignol et al., 2014; Perche et al., 2018). This evidence concerns the gene FMR1 and fragile X syndrome.