Among these reversal DEG candidates, Mt3 plays an important role in ocular neovascularization and its deficiency will exacerbate retinal degeneration (Tsuruma et al., 2012; Choi et al., 2013); Fbn1 (fibrillin 1) expression is required for eye development and its mutation is associated with macular degeneration (Hubmacher et al., 2014; Ratnapriya et al., 2014), suggesting that acupuncture treatment may affect vascularization processes in the retina, and promote neuroprotective outcomes after ONC injury. The gene discussed is FBN1; the disease is retinal degeneration.