The increased levels of IL-6, TNF-α are associated with increased Aβ production, decreased Aβ clearance, tau hyper phosphorylation (Ringheim et al., 1998; Zilka et al., 2012), synaptic dysfunction, and cognitive deficits (Singh-Manoux et al., 2014; Chang et al., 2017). This evidence concerns the gene MAPT and Cognitive impairment.