AKT1 and Alzheimer disease: PI3K/AKT signaling has been found to be impaired in AD patients in previous studies (Wang et al., 2016), Besides AD, the same results have also been observed in other neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) (Recabarren and Alarcon, 2017).