DPYSL2 and Alzheimer disease: While the mechanisms by which the tripeptide or its acetylated diastereomeric form Ac-rER protect or enhance memory are unclear, protein interaction assays indicate that Ac-rER interacts with collapsin response mediator protein 2 (CRMP2), a microtubule binding protein involved in the cytoskeleton (Mileusnic and Rose, 2011) that is known to be disrupted in AD and a possible therapeutic target for AD (Hensley and Kursula, 2016).