BCL2 and neuroblastoma: Lithium suppresses the upregulation of Notch signaling and the postsynaptic protein Homer1b/c to confer cytoprotection in mtSOD1 (G93A) NSC34 cells (hybrid cell line of mouse neuroblastoma and embryonic spinal motor neurons) by increasing the Bcl-2/Bax ratio. These effects are potentiated upon combined treatment with VPA (Wang et al., 2015; Jiang et al., 2016).