In models of diffuse large B cell lymphoma, others have recently elucidated that JAK1 has a classical nuclear localization sequence between its FERM and SH2 domains, demonstrating that JAK1 may influence transcriptional changes using various mechanisms that are independent of STAT phosphorylation at the site of cytoplasmic cytokine receptors (Zhu et al., 2017). The gene discussed is SOAT1; the disease is diffuse large B-cell lymphoma.