MAPT and Alzheimer disease: To address this question, we evaluated the effects of early life caffeine exposure in offspring of the THY-Tau22 transgenic mouse model that progressively develops AD-like hippocampal Tau pathology, with ongoing deficits at 6–8 months of age and a full pathology and memory impairments occurring at 12 months of age (Van der Jeugd et al., 2013).