Tau pathology is observed early in the brain stem and entorhinal cortex (Braak et al., 2011) and its progression from entorhinal cortex, to the hippocampus, and finally neocortex corresponds to the progression of the symptoms in AD (Duyckaerts et al., 1997; Grober et al., 1999) supporting a pivotal role of Tau pathology in AD-related memory impairments. This evidence concerns the gene MAPT and Alzheimer disease.