FOS and Anxiety: Interestingly, exposure of Lrrc4c–/– mice to an anxiety-inducing stimulus (EPM test) revealed similarly lower c-fos signals (relative to WT levels) across multiple brain regions, including the ACC, MO, PIR2, EPd, LS, bed nuclei of the stria terminalis (BNST), RSP, SSp, PVT, and hippocampus (dDG, dCA3, dCA1, and vDG) (Figure 6).