Promising results have been observed with the dual GLP-1/GIP receptor agonist DA-JC4 as well, which decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus, prevented spatial learning dysfunction, attenuated chronic inflammation response in the brain, reduced apoptosis, and reactivated insulin signaling pathways in STZ-induced AD rat model (Shi et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.