The role of TNFα in neurodegeneration has been widely reported, not only in the retina (Yuan and Neufeld, 2000; Tezel et al., 2001; Kitaoka et al., 2006; Agudo et al., 2008; Tezel, 2008; Cueva Vargas et al., 2015; De Groef et al., 2015) but also in neurodegenerative diseases such as Alzheimer's or Parkinson's (Mogi et al., 1994; Cheng et al., 2010). This evidence concerns the gene TNF and Parkinsonism.