ATXN3 and Spinocerebellar ataxia type 3: To determine whether the RSP extract supplementation has therapeutic value for MJD, we used a C. elegans model of ATXN3 neurotoxicity (AT3q130) in which mutant ATXN3 proteins expressed in neurons, caused motility defects and aggregation (Teixeira-Castro et al., 2011).