Apoptotic cell death associated with transcriptional elevated levels of CASP8 has been reported in various neurodegenerative diseases, including Alzheimer’s disease (AD) (Rehker et al., 2017), Parkinson’s disease (PD) (Hartmann et al., 2001), and stroke (Shabanzadeh et al., 2015). The gene discussed is CASP8; the disease is early-onset autosomal dominant Alzheimer disease.