Furthermore, mutations in fatty acid 2-hydroxylase (FA2H) and patatin like phospholipase domain containing 6 (PNPLA6) cause complicated AR-HSP subtypes SPG35 and SPG39, respectively (Rainier et al., 2008; Dick et al., 2010) and mutations in carnitine palmitoyl-transferase (CPT1C) cause pure AD-HSP subtype SPG73 (Rinaldi et al., 2015). This evidence concerns the gene FA2H and Alzheimer disease.