Thus, ketosis suppresses inflammatory signaling (e.g., NLRP3/TLR4/IL-1R/NF-κB) signaling pathways and proinflammatory cytokines/enzymes (e.g., IL-1β and COX-2) that are linked pathophysiologically to epilepsy and other seizure disorders. This evidence concerns the gene NFKB1 and epilepsy.