MTMR2 and centronuclear myopathy: Both CMT4B1 and Centronuclear myopathy (CNM) are caused by mutations in a set of proteins involved in membrane remodeling, suggesting they may have shared pathological pathways (Cowling et al., 2012), and that there may be some redundancy allowing compensation for the loss of function by restoring the balance of enzyme activities (Raimondi et al., 2011; Raess et al., 2017).