GRK2 and cardiomyopathy: Different from the elevated GRK2 expression, elevated NT‐proBNP38 and ANP39 levels suggest the advanced stage of cardiomyopathy, especially for heart failure; plasma cardiotrophin‐1 expression elevated in diabetes patients with cardiac hypertrophy and systolic dysfunction40; and IGFBP‐7 expression was revealed to be related to insulin resistant, cardiac hypertrophy, and cardiac fibrosis.41 These biomarkers represent several putative mechanistic pathways underlying DCM progression.