Disruption of fibronectin fibrils can disrupt the incorporation of type IV collagen, laminin and fibrillin into the extracellular matrix, whereas abnormal deposition of extracellular matrix can lead to glaucoma.15 Furthermore, CTGF was also demonstrated as the matricellular proteins in glaucoma, which plays a role in fibrosis and increased extracellular matrix deposition.16 CTGF might be relevant for the development of elevated IOP, which is considered as a high‐risk factor in glaucoma pathogenesis.17 These results indicated high‐risk genes were key regulators in pathogenesis of glaucoma. This evidence concerns the gene CCN2 and glaucoma.