Junglas et al found that the effects of CTGF on IOP appear to be caused by a modification of the TM actin cytoskeleton.21 Moreover, HIF‐1α protein was up‐regulated in the retina following elevation of IOP.22 These results indicated that crucial regulators could function by implicating in close gene modules, regulating downstream pathway signal of glaucoma. Here, CCN2 is linked to glaucoma.