In another study, it has been revealed that intratumoral injection of STING agonist (c-di-GMP) activated STING/type I IFN signaling in the CD11b+ brain-infiltrating leukocytes (instead of CD11c+ DCs), in which CXCL10 and CCL5 expression was increased and then contributed to the migration of CD8+ T cells into the glioma [37]. This evidence concerns the gene STING1 and central nervous system cancer.