Chemotherapeutic agent DMXAA was firstly designed as an antivascular agent before it was identified to target STING [38], this widely used STING agonist shows rapid and strong antivascular activity in tumors but not in normal tissues, and it is effective to control tumor growth by regulating the vasculatures in various murine cancer models (reviewed in ref. [126]). The gene discussed is STING1; the disease is cancer.