Previous studies demonstrated that the infiltration of CD8+ T cells in the tumor microenvironment is associated with C-X-C motif chemokine ligand 9 (CXCL9), C-C motif chemokine 5 (CCL5) and C-X-C motif chemokine ligand 10 (CXCL10) [95], and the expression of CXCL9 and CXCL10 could be induced in response to type I IFN production by APCs [96], which suggests that APCs play important roles in the trafficking and infiltration of CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.