A study in HPV+ tongue squamous cell carcinoma (TSCC) indicated that activated STING has no impact on cancer cell viability but promotes the induction of immunosuppressive cytokines, such as IL-10, which facilitated the infiltration of Tregs [67], whereas enriched Tregs can express IL-10 to inhibit the proliferation and activity of antigen-specific T cells [104]. Here, IL10 is linked to tongue squamous cell carcinoma.