Consistently, a very recent study also reported that intratumoral injection of other STING agonists (cGAMP or RR-CDA) normalizes the tumor vasculatures in spontaneous or implanted cancers, but this phenomenon is not observed in the STING deficient mice, which implies that STING activation is necessary for the normalization of the tumor vasculatures [59]. This evidence concerns the gene STING1 and cancer.