After depletion of mouse macrophages, the antitumor effect induced by cGAMP disappeared, and the mechanistic analysis revealed that STING-induced migrating tumor macrophages express high levels of T-cell-recruiting chemokines, such as CXCL10 and C-X-C motif chemokine ligand 11 (CXCL11), which then contribute to CD8+ T-cell trafficking to the tumor site [98]. The gene discussed is CD8A; the disease is neoplasm.