Since DCs and type I IFNs play critical roles in the priming and activation of T cells, and it has been revealed that tumor-derived DNA activates DCs and induces production of type I IFN in the tumor microenvironment [34], thus activation of STING signaling in DCs plays important and even exclusive roles in the spontaneous T cell responses against tumors. Here, STING1 is linked to neoplasm.