CDH1 and cancer: Epithelial–mesenchymal transition (EMT) is considered to play an important role in the initial parts of the metastatic cascade-providing cancer cells with invasive, migratory, and cancer stem cell properties, and the induction of EMT leads to the downregulation of E-cadherin, expression of distinct mesenchymal markers such as vimentin, fibronectin, and N-cadherin, and morphological changes [9,10].