CD274 and non-small cell lung carcinoma: Recently, combination of chemotherapy with ICI has demonstrated superiority to chemotherapy alone.25, 26, 27 However, it is unclear which treatment is more appropriate, pembrolizumab alone or combination chemotherapy/ICIs for NSCLC patients with strong expression of PD‐L1 on tumor cells.28 Baseline TB may one of the factors that determine use of single or combination therapy.